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A genetic mutation called ALDH22, predominantly found in East Asians, has been linked to the "Asian glow," a skin reddening reaction to alcohol.
About 8% of the global population, roughly 560 million people, carry this mutation which originated in Southeast China thousands of years ago. Approximately 45% of East Asians experience this flushing when drinking, leading some to use antihistamines to mitigate symptoms or avoid alcohol entirely. Stanford Medicine researchers found that ALDH22 carriers are more vulnerable to acetaldehyde, increasing the risk of liver damage, cancer, and vascular issues.
This mutation significantly elevates the risk of conditions like cardiovascular disease and esophageal cancer, especially with even moderate alcohol consumption. Despite antihistamines alleviating skin flushing, they don't lower acetaldehyde levels, posing risks by masking alcohol toxicity signals. To combat misconceptions, Che-Hong Chen established the Taiwan Alcohol Intolerance Education Society, raising awareness about ALDH2 deficiency and its consequences, even leading to the creation of National Taiwan No Alcohol Day in 2019.
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