- Kōichi Yamadera returns as the voice of Spike Spiegel, who will be played by John Cho in the live-action version of the series.
- Other returning anime cast members include Megumi Hayashibara as Faye, Norio Wakamoto as Vicious, Gara Takashima as Julia, Ken’yû Horiuchi as Gren, Takaya Hashi as the Teddy Bomber, and Tsutomu Taruki and Miki Nagasawa as Punch and Judy.
- Hikaru Midorikawa is back as the voice of Lin, with Romi Park voicing Lin’s younger brother Shin, who was originally portrayed by Nobuyuki Hiyama.
- Masako Isobe will be the new voice of Spike’s mentor Mao, replacing Kazuaki Itō.
- Executive producer André Nemec assured fans that the Netflix series will not be “violating the canon in any direction.”
- “For me, it’s a great surprise and honor that the ‘Cowboy Bebop’ universe has thrived for over 20 years and will continue onward,” said Shinichirō Watanabe, who directed the original anime as well as consulted on the live-action series, according to Entertainment Weekly.
- “‘Cowboy Bebop’ is an important work for me,” voice actor Yamadera was quoted as saying. “I have long anticipated a live-action version. I can feel the strong respect it has toward the anime. I hope that viewers will see the atmosphere of the Spike character that I previously portrayed in John Cho’s performance, who is skillfully taking on the role in this version. There are also many settings and developments that can only be pulled off in a live-action series. I hope that both people who love ‘Cowboy Bebop’ and those who are new to the title can enjoy this new series!”